Predictors of liver disease progression in people living with HIV-HBV co-infection on antiretroviral therapy

KP Singh; A Avihingsanon; JM Zerbato; W Zhao; S Braat; S Tennakoon; A Rhodes; GV Matthews; CK Fairley; J Sasadeusz; M Crane; J Audsley; SR Lewin

Journal article

Predictors of liver disease progression in people living with HIV-HBV co-infection on antiretroviral therapy

KP Singh, A Avihingsanon, JM Zerbato, W Zhao, S Braat, S Tennakoon, A Rhodes, GV Matthews, CK Fairley, J Sasadeusz, M Crane, J Audsley, SR Lewin

Ebiomedicine | Published : 2024

DOI: 10.1016/j.ebiom.2024.105054

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Abstract

Background: In people living with HIV-HBV, liver fibrosis progression can occur even with suppressive antiretroviral therapy (ART). We investigated the relationship between liver fibrosis and biomarkers of inflammation, apoptosis, and microbial translocation. Methods: In this observational cohort study adults living with HIV-HBV already on effective ART were recruited in Australia and Thailand and followed for 3 years including 6 monthly clinical review and blood tests and annual transient elastography. Differences in clinical and laboratory predictors of liver fibrosis progression were tested followed by regression analysis adjusted for CD4+ T-cells at study entry. A linear mixed model was ..

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University of Melbourne Researchers

Kasha Singh Author

Wei Zhao Author

Sabine Braat Author

Joseph Sasadeusz Author

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Awarded by NHMRC

Funding Acknowledgements

This work was supported by NHMRC project grant 1101836; NHMRC practitioner fellowship 1138581 and NHMRC program grant 1149990. The funder had no role in study design, data collection, data analysis, interpretation, writing of this manuscript or decision to submit for publication.